Ontology highlight
ABSTRACT:
SUBMITTER: Ronayne EK
PROVIDER: S-EPMC8223065 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Ronayne Estelle K EK Peters Shaun C SC Gish Joseph S JS Wilson Celena C Spencer H Trent HT Doering Christopher B CB Lollar Pete P Spiegel P Clint PC Childers Kenneth C KC
Frontiers in immunology 20210610
Factor VIII (fVIII) is a procoagulant protein that binds to activated factor IX (fIXa) on platelet surfaces to form the intrinsic tenase complex. Due to the high immunogenicity of fVIII, generation of antibody inhibitors is a common occurrence in patients during hemophilia A treatment and spontaneously occurs in acquired hemophilia A patients. Non-classical antibody inhibitors, which block fVIII activation by thrombin and formation of the tenase complex, are the most common anti-C2 domain pathog ...[more]