The impact of Wilson disease on myocardial tissue and function: a cardiovascular magnetic resonance study.

ABSTRACT:

Background

Systemic effects of altered serum copper processing in Wilson Disease (WD) might induce myocardial copper deposition and consequently myocardial dysfunction and structural remodeling. This study sought to investigate the prevalence, manifestation and predictors of myocardial tissue abnormalities in WD patients.

Methods

We prospectively enrolled WD patients and an age-matched group of healthy individuals. We applied cardiovascular magnetic resonance (CMR) to analyze myocardial function, strain, and tissue characteristics. A subgroup analysis of WD patients with predominant neurological (WD-neuro⁺) or hepatic manifestation only (WD-neuro^-) was performed.

Results

Seventy-six patients (37 years (27-49), 47% women) with known WD and 76 age-

SUBMITTER: Salatzki J 

PROVIDER: S-EPMC8223377 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature