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Rapid synthesis of the core scaffold of crinane and haemanthamine through a multi-component approach.


ABSTRACT: A rapid synthesis of the core structures of crinane and haemanthamine has been developed, enabled by a multicomponent approach. This work constitutes a formal synthesis of crinane and sets the stage for access to both families of natural products and key analogues. A key highlight of the approach is the modularity of the core synthesis, overcoming existing challenges for these scaffolds and providing a path to explore site-selective oxidation to expand the scope of molecules accessible from common intermediates.

SUBMITTER: Massaro NP 

PROVIDER: S-EPMC8224825 | biostudies-literature |

REPOSITORIES: biostudies-literature

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