Zebrafish, an In Vivo Platform to Screen Drugs and Proteins for Biomedical Use.

ABSTRACT: The nearly simultaneous convergence of human genetics and advanced molecular technologies has led to an improved understanding of human diseases. At the same time, the demand for drug screening and gene function identification has also increased, albeit time- and labor-intensive. However, bridging the gap between in vitro evidence from cell lines and in vivo evidence, the lower vertebrate zebrafish possesses many advantages over higher vertebrates, such as low maintenance, high fecundity, light-induced spawning, transparent embryos, short generation interval, rapid embryonic development, fully sequenced genome, and some phenotypes similar to human diseases. Such merits have popularized the zebrafish as a model system for biomedical and pharmaceutical studies, including drug screening. Here

SUBMITTER: Lee HC 

PROVIDER: S-EPMC8225009 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature