Ontology highlight
ABSTRACT:
SUBMITTER: Dou S
PROVIDER: S-EPMC8225388 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Dou Shuaijie S Li Guoxian G Li Ge G Hou Chunmei C Zheng Yang Y Tang Lili L Gao Yang Y Mo Rongliang R Li Yuxiang Y Wang Renxi R Shen Beifen B Zhang Jun J Han Gencheng G
eLife 20210610
Nuclear factor 90 (NF90) is a novel virus sensor that serves to initiate antiviral innate immunity by triggering stress granule (SG) formation. However, the regulation of the NF90-SG pathway remains largely unclear. We found that Tim-3, an immune checkpoint inhibitor, promotes the ubiquitination and degradation of NF90 and inhibits NF90-SG-mediated antiviral immunity. Vesicular stomatitis virus (VSV) infection induces the up-regulation and activation of Tim-3 in macrophages, which in turn recrui ...[more]