Spearheading future omics analyses using dyngen, a multi-modal simulator of single cells.
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ABSTRACT: We present dyngen, a multi-modal simulation engine for studying dynamic cellular processes at single-cell resolution. dyngen is more flexible than current single-cell simulation engines, and allows better method development and benchmarking, thereby stimulating development and testing of computational methods. We demonstrate its potential for spearheading computational methods on three applications: aligning cell developmental trajectories, cell-specific regulatory network inference and estimation of RNA velocity.
SUBMITTER: Cannoodt R
PROVIDER: S-EPMC8225657 | biostudies-literature |
REPOSITORIES: biostudies-literature
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