Spearheading future omics analyses using dyngen, a multi-modal simulator of single cells.

ABSTRACT: We present dyngen, a multi-modal simulation engine for studying dynamic cellular processes at single-cell resolution. dyngen is more flexible than current single-cell simulation engines, and allows better method development and benchmarking, thereby stimulating development and testing of computational methods. We demonstrate its potential for spearheading computational methods on three applications: aligning cell developmental trajectories, cell-specific regulatory network inference and estimation of RNA velocity.

SUBMITTER: Cannoodt R 

PROVIDER: S-EPMC8225657 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature