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Ubiquitin-Conjugating Enzymes in Cancer.

ABSTRACT: The ubiquitin-mediated degradation system is responsible for controlling various tumor-promoting processes, including DNA repair, cell cycle arrest, cell proliferation, apoptosis, angiogenesis, migration and invasion, metastasis, and drug resistance. The conjugation of ubiquitin to a target protein is mediated sequentially by the E1 (activating)‒E2 (conjugating)‒E3 (ligating) enzyme cascade. Thus, E2 enzymes act as the central players in the ubiquitination system, modulating various pathophysiological processes in the tumor microenvironment. In this review, we summarize the types and functions of E2s in various types of cancer and discuss the possibility of E2s as targets of anticancer therapeutic strategies.

SUBMITTER: Bui QT

PROVIDER: S-EPMC8227520 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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Ubiquitin-Conjugating Enzymes in Cancer.

Bui Quyen Thu QT Hong Jeong Hee JH Kwak Minseok M Lee Ji Yeon JY Lee Peter Chang-Whan PC

Cells 20210604 6

The ubiquitin-mediated degradation system is responsible for controlling various tumor-promoting processes, including DNA repair, cell cycle arrest, cell proliferation, apoptosis, angiogenesis, migration and invasion, metastasis, and drug resistance. The conjugation of ubiquitin to a target protein is mediated sequentially by the E1 (activating)‒E2 (conjugating)‒E3 (ligating) enzyme cascade. Thus, E2 enzymes act as the central players in the ubiquitination system, modulating various pathophysiol ...[more]

PMID: 34199813

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