Comparative effectiveness of five fecal immunochemical tests using colonoscopy as the gold standard: study protocol.

ABSTRACT:

Background

There are nearly 50,000 colorectal cancer (CRC) deaths in the United States each year. CRC is curable if detected in its early stages. Fecal immunochemical tests (FITs) can detect precursor lesions and many can be analyzed at the point-of-care (POC) in physician offices. However, there are few data to guide test selection. Broader use of FITs could make CRC screening more accessible, especially in resource-poor settings.

Methods

A total of 3600 racially and ethnically diverse individuals aged 50 to 85 years having either a screening or surveillance colonoscopy will be recruited. Each participant will complete five FITs on a single stool sample. Test characteristics for each FIT for advanced colorectal neoplasia (ACN) will be calculated using colonoscopy as the gol

SUBMITTER: Levy BT 

PROVIDER: S-EPMC8227954 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature