Folding and Stability of Ankyrin Repeats Control Biological Protein Function.

ABSTRACT: Ankyrin repeat proteins are found in all three kingdoms of life. Fundamentally, these proteins are involved in protein-protein interaction in order to activate or suppress biological processes. The basic architecture of these proteins comprises repeating modules forming elongated structures. Due to the lack of long-range interactions, a graded stability among the repeats is the generic properties of this protein family determining both protein folding and biological function. Protein folding intermediates were frequently found to be key for the biological functions of repeat proteins. In this review, we discuss most recent findings addressing this close relation for ankyrin repeat proteins including DARPins, Notch receptor ankyrin repeat domain, IκBα inhibitor of NFκB, and CDK inhibitor p1

SUBMITTER: Kumar A 

PROVIDER: S-EPMC8229355 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature