Colesevelam Reduces Ethanol-Induced Liver Steatosis in Humanized Gnotobiotic Mice.
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ABSTRACT:
SUBMITTER: Cabre N
PROVIDER: S-EPMC8232222 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
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Colesevelam Reduces Ethanol-Induced Liver Steatosis in Humanized Gnotobiotic Mice.
Cabré Noemí N Duan Yi Y Llorente Cristina C Conrad Mary M Stern Patrick P Yamashita Dennis D Schnabl Bernd B
Cells 20210614 6
Alcohol-related liver disease is associated with intestinal dysbiosis. Functional changes in the microbiota affect bile acid metabolism and result in elevated serum bile acids in patients with alcohol-related liver disease. The aim of this study was to identify the potential role of the bile acid sequestrant colesevelam in a humanized mouse model of ethanol-induced liver disease. We colonized germ-free (GF) C57BL/6 mice with feces from patients with alcoholic hepatitis and subjected humanized mi ...[more]
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