Inferring the heritability of large-scale functional networks with a multivariate ACE modeling approach.

ABSTRACT: Recent evidence suggests that the human functional connectome is stable at different timescales and is unique. These characteristics posit the functional connectome not only as an individual marker but also as a powerful discriminatory measure characterized by high intersubject variability. Among distinct sources of intersubject variability, the long-term sources include functional patterns that emerge from genetic factors. Here, we sought to investigate the contribution of additive genetic factors to the variability of functional networks by determining the heritability of the connectivity strength in a multivariate fashion. First, we reproduced and extended the connectome fingerprinting analysis to the identification of twin pairs. Then, we estimated the heritability of functional networ

SUBMITTER: Ribeiro FL 

PROVIDER: S-EPMC8233119 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature