Incidence and Dosimetric Predictors of Radiation-Induced Gastric Bleeding After Chemoradiation for Esophageal and Gastroesophageal Junction Cancer.

ABSTRACT:

Purpose

To determine the incidence and predictors of gastric bleeding after chemoradiation for esophageal or gastroesophageal junction cancer.

Methods and materials

We reviewed patients receiving chemoradiation to at least 41.4 Gy for localized esophageal cancer whose fields included the stomach and who did not undergo surgical resection. The primary endpoint was grade ≥3 gastric hemorrhage (GB3+). Comprehensive stomach dose-volume parameters were collected, and stomach dose-volume histograms were generated for analysis.

Results

A total of 145 patients met our inclusion criteria. Median prescribed dose was 50.4 Gy (range, 41.4-56 Gy). Median stomach Dmax was 53.0 Gy (1.0-62.7 Gy), and median stomach V40, V45, and V50 Gy were 112 cm³ (0-667 cm³),

SUBMITTER: Montovano M 

PROVIDER: S-EPMC8233466 | biostudies-literature | 2021 May-Jun

REPOSITORIES: biostudies-literature