Riding the COVID-19 Tsunami in India: A nephrologist's perspective.
Ontology highlight
ABSTRACT:
SUBMITTER: Mohan K
PROVIDER: S-EPMC8233545 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Publications
Riding the COVID-19 Tsunami in India: A nephrologist's perspective.
Mohan Krithika K Parikh Namrata N
Kidney international reports 20210626 8
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Project description:High throughput sequencing is performed on mRNA isolated from whole blood of adult Covid-19 patients, bacterial coinfection with Covid-19 and healthy controls in a South Indian cohort. Samples were collected from individuals at the time of hospitalization or visit to clinic. The Covid-19 samples are categorized by severeity.
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Project description:ObjectiveIn this COVID-19 pandemic, there are not many sound studies focusing on the extensive socioeconomic impact ushered in with this disaster. This work aims to understand the thought of the youth, their opinions and understanding of various aspects of the COVID-19 pandemic.MethodologyUsing a combined qualitative-quantitative approach, Q-method, we tried to assess people's discernment from different perspectives. This was done through a questionnaire survey method during the national-level lockdown 1.0 in India.ResultsWe have differentiated the perceptions of youth respondents into seven factors, including six subdimensions, on COVID-19 pandemic (viz., science, society, environment, economy, politics, and religion). The choices and opinions have been segregated into two major groups: quantitative and qualitative.ConclusionThis work yielded a firsthand ground-level insight into the comprehensive yet diverse responses from youths regarding the COVID-19 pandemic in India. There are various topics that arise from this study, for example, misinformation, misinterpretation of science, dubious nature of faith in governance and policy, turbid understanding of strategy, polarization of opinion, and so forth. Following this work of identification, the next steps would be to understand how to mitigate the problems toward betterment in the COVID-19 pandemic situation or similar widespread crisis events in the foreseeable future.
| S-EPMC7404431 | biostudies-literature
Project description:The outbreak of novel and recent coronavirus disease 2019, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, has made an emergency throughout the world. In India, the outspread of the pandemic was observed on 3 March 2020, and after that exponential growth in the cases was observed in the country. Owing to the widespread transmission, high population density, high testing capacity and ineffective treatment, a continuous rise in cases was observed due to the pandemic in India. In this paper, we have discussed the trend and spread of COVID-19 spread in India with time, history of initial confirmed cases, the impact of phased manner lockdown, age- and gender-wise trend of cases and comparison of cases with the other most affected countries. The study uses exploratory data analysis to describe the current situation of COVID-19 cases in India till 16 August 2020, with the help of data from the Ministry of Health and Family Welfare, Government of India (GOI) and the World Health Organization (WHO). As of August 16, the total number of confirmed cases in India crossed 2.5 million marks with over 50,000 causalities. With more patients recovering and being discharged from hospitals and home isolation (in case of mild and moderate cases), the total recoveries have crossed the 1.8 million mark with a recovery rate of more than 70% and case fatality rate of 1.94% which is maintained below the global average and is on a continuous positive slide. The study also enlightens the preventive and stringent measures taken by India to combat the COVID-19 situation along with the future prospects. The GOI is following its proactive and preemptive approach for management, prevention and containment of COVID-19 in collaboration with the WHO.
| S-EPMC7456788 | biostudies-literature
Project description:BackgroundMotorcycles are one of the most commonly used transportation modes in low and middle-income countries. In India, motorized two-wheelers comprise 70% of the total vehicle population, and motorcycle users are considered the most vulnerable road users. It is essential to understand the risky riding behaviour and associated factors among the motorcyclists to develop evidence-based traffic safety programs targeting motorcycle riders. The purpose of the current study was two-fold. First, it aimed to determine the appropriate structure of a modified version of the MRBQ among young riders in Manipal, India. Second, it assessed to what extent MRBQ factors were associated with self-reported crash involvement and violations.MethodsThe motorcycle rider behaviour questionnaire (MRBQ) is a 43-item scale that assesses five aspects of risky motorcycle rider behaviour, i.e., violations, control errors, traffic errors, stunts, and protective equipment. The MRBQ, along with measures of socio-demographic variables and the number of motorcycle crashes, was filled out by 300 young motorcycle riders who were in the age group of 18-25 years and had been riding for at least the past three years (93% males, 92.3% students).ResultsFive factors emerged out of the MRBQ after an exploratory factor analysis: traffic errors, control errors, stunts, protective equipment, and violations. Cronbach's alpha for these factors ranged from .66 to .82. Reports of performing stunts and committing violations were positively associated with self-reported near-crash experiences over the past three months. Riders reporting stunts, violations and using a motorcycle of 125-200 cc reported having received more fines in the last three months. These findings were confirmed in both univariate and multivariate binary logistic regression models.ConclusionThe study assessed the factor structure of a modified version MRBQ and the extracted factors associations with self-reported crash involvement. The factor structure revealed in the current study is consistent with MRBQ factor structures found in other countries. However, the support for a relationship between MRBQ factors and self-reported crashes was less significant. The findings suggest that if replicated by future studies, local policymakers are advised to focus on the five MRBQ factors while planning future interventions to achieve a reduction in the number of road crashes among motorcyclists.
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Project description:Mentorship transforms careers. Yet, a lack of awareness of the need for a mentor is ironically, a pandemic. The pandemic has brought a host of challenges for the academic researcher. As bench work has come to a standstill, there is not just reduced productivity, but a significant increase in fear, anxiety, and depression amongst students. Our survey of -150 graduate students of Life Sciences courses confirmed the anecdotal observation that > 75% did not have a mentor other than their academic guide. Over the past six months, we have been exploring the requirements of mentee-mentor relationships during both normal times and during the COVID-19 pandemic. Written primarily from the mentee perspective, we have described the (i) criteria and roles of an ideal mentor and mentee, (ii) the problems faced by the mentee, and (iii) the solutions to address these challenges. We have described the experience of 10 mentees with a mentor during these challenging times, in which we discussed scientific, psychological, and practical support for each other. We provide some recommendations based on previous work in mentor–mentee interactions and explore the critical nature of this delicate relationship for a successful career. Supplementary Information The online version contains supplementary material available at 10.1007/s43538-021-00002-z.
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Project description:The recent outbreak in severe acute respiratory syndrome - coronavirus-2 (SARS-CoV-2) has demonstrated the complete inability of nations across the world to cope with the pressures of a global pandemic, especially one in which the only current feasible treatments are those which deal with the symptoms alone and not the viral cause. As the death toll rises, scientists begin to fall toward new avenues of research, with novelty showing itself to be an incredible and so far, underrated resource. In this case, the use of biosurfactants in dealing with this pandemic justifies extensive study with their potential applications being in the prevention of viral spread; dealing with the symptoms that develop after the incubation period; directly targeting viral infected cells and preventing the spread of the virus throughout the host, all in addition to also acting as potential drug delivery systems and cleaning agents. This extensive avenue of biosurfactants owes to the simplicity in their amphiphilic structure which permits them to interact directly with the lipid membrane of the coronavirus, in a way which wouldn't be of significant threat to the host. Although it could possibly interact and affect the virus, it could also affect human internal organs/cells by interacting with lipid membrane, if (biosurfactant is) ingested, and it still needs further studies in human models. The structure of the coronavirus, in this case SARS-CoV-2, is detrimentally dependent on the integrity of its lipid membrane which encloses its vital proteins and RNA. Biosurfactants possess the innate ability to threaten this membrane, a result of their own hydrophobic domains across their amphiphilic structure. With biosurfactants additionally being both natural and sustainable, while also possessing a remarkably low cytotoxicity, it is of no doubt that they are going to be of increasing significance in dealing with the current pandemic.
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