New RAD51 Inhibitors to Target Homologous Recombination in Human Cells.

ABSTRACT: Targeting DNA repair proteins with small-molecule inhibitors became a proven anti-cancer strategy. Previously, we identified an inhibitor of a major protein of homologous recombination (HR) RAD51, named B02. B02 inhibited HR in human cells and sensitized them to chemotherapeutic drugs in vitro and in vivo. Here, using a medicinal chemistry approach, we aimed to improve the potency of B02. We identified the B02 analog, B02-isomer, which inhibits HR in human cells with significantly higher efficiency. We also show that B02-iso sensitizes triple-negative breast cancer MDA-MB-231 cells to the PARP inhibitor (PARPi) olaparib.

SUBMITTER: Shkundina IS 

PROVIDER: S-EPMC8235719 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature