Adult neurogenesis mediates forgetting of multiple types of memory in the rat.

ABSTRACT: The formation and retention of hippocampus-dependent memories is impacted by neurogenesis, a process that involves the production of new neurons in the dentate gyrus of the hippocampus. Recent studies demonstrate that increasing neurogenesis after memory formation induces forgetting of previously acquired memories. Neurogenesis-induced forgetting was originally demonstrated in mice, but a recent report suggests that the same effect may be absent in rats. Although a general species difference is possible, other potential explanations for these incongruent findings are that memories which are more strongly reinforced become resilient to forgetting or that perhaps only certain types of memories are affected. Here, we investigated whether neurogenesis-induced forgetting occurs in rats using se

SUBMITTER: Scott GA 

PROVIDER: S-EPMC8236170 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature