Parental occupation and childhood germ cell tumors: a case-control study in Denmark, 1968-2016.

ABSTRACT:

Purpose

To examine associations between parental occupation and childhood germ cell tumors (GCTs) in offspring while distinguishing by common histologic subtype (i.e., yolk sac tumor and teratoma).

Methods

This population-based case-control study included childhood GCT cases in Denmark diagnosed 1968-2015 (< 16 years old at diagnosis) and sex and birth year-matched controls. Demographic information and parental employment histories were obtained from Danish registries. Parental occupation was assessed by industry; job-exposure matrices were used to examine specific occupational exposures (i.e., potentially carcinogenic organic solvents and social contact). Conditional multivariable logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals

SUBMITTER: Hall C 

PROVIDER: S-EPMC8236473 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature