Shared DNA methylation signatures in childhood allergy: The MeDALL study.

ABSTRACT:

Background

Differential DNA methylation associated with allergy might provide novel insights into the shared or unique etiology of asthma, rhinitis, and eczema.

Objective

We sought to identify DNA methylation profiles associated with childhood allergy.

Methods

Within the European Mechanisms of the Development of Allergy (MeDALL) consortium, we performed an epigenome-wide association study of whole blood DNA methylation by using a cross-sectional design. Allergy was defined as having symptoms from at least 1 allergic disease (asthma, rhinitis, or eczema) and positive serum-specific IgE to common aeroallergens. The discovery study included 219 case patients and 417 controls at age 4 years and 228 case patients and 593 controls at age 8 years from 3 birth cohorts, with r

SUBMITTER: Xu CJ 

PROVIDER: S-EPMC8238013 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature