Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer's disease.

ABSTRACT: Neuroinflammation is associated with Alzheimer's disease, but the application of cerebrospinal fluid measures of inflammatory proteins may be limited by overlapping pathways and relationships between them. In this work, we measure 15 cerebrospinal proteins related to microglial and T-cell functions, and show them to reproducibly form functionally-related groups within and across diagnostic categories in 382 participants from the Alzheimer's Disease Neuro-imaging Initiative as well participants from two independent cohorts. We further show higher levels of proteins related to soluble tumor necrosis factor receptor 1 are associated with reduced risk of conversion to dementia in the multi-centered (p = 0.027) and independent (p = 0.038) cohorts of people with mild cognitive impairment due to

SUBMITTER: Hu WT 

PROVIDER: S-EPMC8238986 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature