Characterization of perfusion decellularized whole animal body, isolated organs, and multi-organ systems for tissue engineering applications.
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ABSTRACT:
SUBMITTER: Taylor DA
PROVIDER: S-EPMC8239446 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
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Characterization of perfusion decellularized whole animal body, isolated organs, and multi-organ systems for tissue engineering applications.
Taylor Doris A DA Kren Stefan M SM Rhett Katrina K Robertson Matthew J MJ Morrissey Jacquelynn J Rodriguez Osman E OE Virk Hassan H Chacon-Alberty Lourdes L Curty da Costa Ernesto E Mesquita Fernanda C P FCP Sampaio Luiz C LC Hochman-Mendez Camila C
Physiological reports 20210601 12
To expand the application of perfusion decellularization beyond isolated single organs, we used the native vasculature of adult and neonatal rats to systemically decellularize the organs of a whole animal in situ. Acellular scaffolds were generated from kidney, liver, lower limb, heart-lung system, and a whole animal body, demonstrating that perfusion decellularization technology is applicable to any perfusable tissue, independent of age. Biochemical and histological analyses demonstrated that o ...[more]
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