Synergistic dual-modified liposome improves targeting and therapeutic efficacy of bone metastasis from breast cancer.

ABSTRACT: Breast cancer frequently metastasizes to bone, where it leads to poor clinical prognosis. Due to the peculiarity of the bone microstructure, the uptake of drugs often happens at non-targeted sites, which produces a similar cytotoxicity in both cancerous and healthy cells. In this study, a rational strategy was implemented to take advantage of a combination of both an octapeptide with eight repeating sequences of aspartate (Asp₈) and folate to create a more selective and efficient drug delivery system to target cancer cells in bone tissue. Asp₈ and folate were conjugated to the distal ends of DSPE-PEG₂₀₀₀-maleimide and DSPE-PEG₂₀₀₀-amine to create DSPE-PEG₂₀₀₀-Asp₈ and DSPE-PEG₂₀₀₀-Folate, respectively, which were

SUBMITTER: Ke X 

PROVIDER: S-EPMC8241154 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature