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3DBionotes COVID-19 Edition.

ABSTRACT:

Summary

The web platform 3DBionotes-WS integrates multiple Web Services and an interactive Web Viewer to provide a unified environment in which biological annotations can be analyzed in their structural context. Since the COVID-19 outbreak, new structural data from many viral proteins have been provided at a very fast pace. This effort includes many cryogenic Electron Microscopy (cryo-EM) studies, together with more traditional ones (X-rays, NMR), using several modeling approaches and complemented with structural predictions. At the same time, a plethora of new genomics and interactomics information (including fragment screening and structure-based virtual screening efforts) have been made available from different servers. In this context we have developed 3DBionotes-COVID-19 as an answer to: (1) The need to explore multi-omics data in a unified context with a special focus on structural information and (2) the drive to incorporate quality measurements, especially in the form of advanced validation metrics for cryogenic Electron Microscopy.

Availability

https://3dbionotes.cnb.csic.es/ws/covid19.

Supplementary information

Supplementary data are available at Bioinformatics online.

SUBMITTER: Macias JR

PROVIDER: S-EPMC8241415 | biostudies-literature |

REPOSITORIES: biostudies-literature

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