Discontinuation Rate of Newly Prescribed Donepezil in Alzheimer's Disease Patients in Asia.

ABSTRACT:

Background and purpose

The rate of donepezil discontinuation and the underlying reasons for discontinuation in Asian patients with Alzheimer's disease (AD) are currently unknown. We aimed to determine the treatment discontinuation rates in AD patients who had newly been prescribed donepezil in routine clinical practice in Asia.

Methods

This 1-year observational study involved 38 institutions in seven Asian countries, and it evaluated 398 participants aged 50-90 years with a diagnosis of probable AD and on newly prescribed donepezil monotherapy. The primary endpoint was the rate of donepezil discontinuation over 1 year. Secondary endpoints included the reason for discontinuation, treatment duration, changes in cognitive function over the 1-year study period, and compliance as

SUBMITTER: Park KH 

PROVIDER: S-EPMC8242303 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature