Dataset Information

Persistence of Antibody and Cellular Immune Responses in COVID-19 patients over Nine Months after Infection.

ABSTRACT:

Background

The duration of humoral and T and cell response after the infection of SARS-CoV-2 remains unclear.

Methods

We performed a cross-sectional study to assess the virus-specific antibody and memory T and B cell responses in COVID-19 patients up to 343 days after infection. Neutralizing antibodies and antibodies against the receptor-binding domain, spike, and nucleoprotein of SARS-CoV-2 were measured. Virus-specific memory T and B cell responses were analyzed.

Results

We enrolled 59 COVID-19 patients, including 38 moderate, 16 mild, and five asymptomatic patients; 31 (52.5%) were men, and 28 (47.5%) were women. The median age was 41 (interquartile range [IQR]: 30-55). The median day from symptom onset to enrollment was 317 days (range 257 to 343 days). We found that approximately 90% of patients still have detectable IgG antibodies against spike and nucleocapsid proteins and neutralizing antibodies against pseudovirus, whereas ~60% of patients had detectable IgG antibodies against receptor binding domain and surrogate virus-neutralizing antibodies. SARS-CoV-2-specific IgG + memory B cell and IFN-γ secreting T cell responses were detectable in over 70% of patients.

Conclusions

SARS-CoV-2-specific immune memory response persists in most patients nearly one year after infection, which provides a promising sign for prevention from reinfection and vaccination strategy.

SUBMITTER: Yao L

PROVIDER: S-EPMC8243600 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Publications

Persistence of Antibody and Cellular Immune Responses in Coronavirus Disease 2019 Patients Over Nine Months After Infection.

Yao Lin L Wang Guo-Lin GL Shen Yuan Y Wang Zhuang-Ye ZY Zhan Bing-Dong BD Duan Li-Jun LJ Lu Bing B Shi Chao C Gao Yu-Meng YM Peng Hong-Hong HH Wang Guo-Qiang GQ Wang Dong-Mei DM Jiang Ming-Dong MD Cao Guo-Ping GP Ma Mai-Juan MJ

The Journal of infectious diseases 20210801 4

<h4>Background</h4>The duration of humoral and T and B cell response after the infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains unclear.<h4>Methods</h4>We performed a cross-sectional study to assess the virus-specific antibody and memory T and B cell responses in coronavirus disease 2019 (COVID-19) patients up to 343 days after infection. Neutralizing antibodies and antibodies against the receptor-binding domain, spike, and nucleoprotein of SARS-CoV-2 were measur ...[more]

PMID: 33978754

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