Dataset Information

Omega-3 polyunsaturated fatty acids modify the inverse association between systemic inflammation and cardiovascular fitness.

ABSTRACT:

Background and objective

Exercise increases quality of life and lowers all-cause mortality, likely by preventing cardiovascular disease. Although the beneficial effects of exercise are linked with reductions in chronic inflammation, individual responses vary and factors that contribute to the anti-inflammatory effects of cardiovascular fitness remain largely undefined. We sought to investigate the role of fatty acids in the inverse relationship between inflammation and cardiovascular fitness.

Approach and results

In this cross-sectional study using data from 435 participants in NHANES and linear regression models with CRP as the outcome, we observed significant negative interactions between VO₂max and omega-3 polyunsaturated fatty acids (PUFAs) but not saturated, monounsaturated, or omega-6 PUFAs. When stratified by omega-3 PUFA tertiles, participants in the medium tertile, but not low tertile, show an enhanced negative association between VO₂max and CRP, with a -32.0% difference (95% CI: -44.95, -15.9%) per 10 mL/kg/min of VO₂max. Exploratory factor analysis identified five unique dietary fatty acid (FA) profiles. The FA profile consisting predominantly of omega-3 PUFA had the strongest negative association for VO₂max and CRP, with a -28.2% difference in CRP (95% CI: -43.4, -8.9) per 10 mL/kg/min of VO₂max. We also found that alpha-linolenic acid (ALA) and docosahexaenoic acid (DHA) enhanced the negative association between VO₂max and CRP, suggesting that the anti-inflammatory response to VO₂max capacity is associated with ALA and DHA levels. Males, Whites, and individuals with lower BMI were more sensitive to the effects of omega-3 PUFAs, while having high SFA levels attenuated the benefit.

Conclusions

This study suggests that omega-3 PUFAs are effect modifiers for VO₂max and CRP and that the anti-inflammatory benefits of increasing cardiovascular fitness are associated with omega-3 PUFAs.

SUBMITTER: Farley G

PROVIDER: S-EPMC8243787 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Omega-3 polyunsaturated fatty acids modify the inverse association between systemic inflammation and cardiovascular fitness.

Farley Gabrielle G Riggs Daniel W DW Bhatnagar Aruni A Hellmann Jason J

Clinical nutrition (Edinburgh, Scotland) 20210211 6

<h4>Background and objective</h4>Exercise increases quality of life and lowers all-cause mortality, likely by preventing cardiovascular disease. Although the beneficial effects of exercise are linked with reductions in chronic inflammation, individual responses vary and factors that contribute to the anti-inflammatory effects of cardiovascular fitness remain largely undefined. We sought to investigate the role of fatty acids in the inverse relationship between inflammation and cardiovascular fit ...[more]

PMID: 33618966

Similar Datasets

Project description:ObjectiveThis study aimed to explore the association between serum omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) and biological aging, along with the potential mediating role of systemic immune inflammation (SII).MethodsData from the National Health and Nutrition Examination Survey (NHANES) 2011-2014 were used for analyses. Accelerated aging in participants was assessed by calculating the difference between phenotypic age (PhenoAge) and chronological age. Weighted multivariate linear regression models and subgroup analysis were used to investigate the correlation between serum n-3 and n-6 PUFAs and accelerated aging, and restricted cubic spline (RCS) model was applied to explore potential nonlinear relationships. We further conducted mediation analyses to assess the role of SII in these relationships. Additionally, weighted quantile sum (WQS) regression and quantile g-computation (QGC) models were conducted to investigate the mixed effects of serum PUFAs and identify the key contributor.ResultsA total of 3376 participants were enrolled in this study. In multivariate linear regression models, eight of the twelve individual serum PUFAs showed a significantly negative association with PhenoAge acceleration, Specifically, per-unit increases in linoleic acid (LA), gamma-linolenic acid (GLA), arachidonic acid (AA), alpha-linolenic acid (ALA), stearidonic acid (SDA), eicosapentaenoic acid (EPA), docosapentaenoic acid (n-3 DPA), and docosahexaenoic acid (DHA) were all associated with reduced PhenoAge acceleration (P < 0.05, respectively). Subgroup analysis demonstrated robust consistence results when stratified by age, sex, and race/ethnicity. L-shaped nonlinear relationships were observed between PhenoAge acceleration with total n-6 PUFAs, LA and ALA (all P for nonlinear < 0.05). Mediation analyses indicated that SII mediated the relationship between serum PUFAs and reduced PhenoAge acceleration. Mixed-effects analysis using WQS and QGC models revealed that the combined effect of serum PUFAs on reducing PhenoAge acceleration, with DHA showing the strongest significant contribution.ConclusionsThis study demonstrated that higher levels of certain PUFAs were associated with a reduction in PhenoAge acceleration either individually or in combination, with DHA having the most prominent effect in mixed effects. The SII mediated these relationships, suggesting that PUFAs may slow biological aging by reducing inflammation. These findings highlighted the potential role of PUFAs in mitigating accelerated aging and their implications for aging-related health interventions.

Project description:BackgroundAlthough omega-6 polyunsaturated fatty acids (n-6 PUFA) have been recommended to reduce coronary heart disease (CHD), controversy remains about benefits versus harms, including concerns over theorized proinflammatory effects of n-6 PUFA. We investigated associations of circulating n-6 PUFA including linoleic acid (the major dietary PUFA), γ-linolenic acid, dihomo-γ-linolenic acid, and arachidonic acid, with total and cause-specific mortality in the Cardiovascular Health Study, a community-based U.S. cohort.Methods and resultsAmong 2792 participants(aged ≥65 years) free of cardiovascular disease at baseline, plasma phospholipid n-6 PUFA were measured at baseline using standardized methods. All-cause and cause-specific mortality, and total incident CHD and stroke, were assessed and adjudicated centrally. Associations of PUFA with risk were assessed by Cox regression. During 34 291 person-years of follow-up (1992-2010), 1994 deaths occurred (678 cardiovascular deaths), with 427 fatal and 418 nonfatal CHD, and 154 fatal and 399 nonfatal strokes. In multivariable models, higher linoleic acid was associated with lower total mortality, with extreme-quintile hazard ratio =0.87 (P trend=0.005). Lower death was largely attributable to cardiovascular disease causes, especially nonarrhythmic CHD mortality (hazard ratio, 0.51; 95% confidence interval, 0.32-0.82; P trend=0.001). Circulating γ-linolenic acid, dihomo-γ-linolenic acid, and arachidonic acid were not significantly associated with total or cause-specific mortality (eg, for arachidonic acid and CHD death, the extreme-quintile hazard ratio was 0.97; 95% confidence interval, 0.70-1.34; P trend=0.87). Evaluated semiparametrically, linoleic acid showed graded inverse associations with total mortality (P=0.005). There was little evidence that associations of n-6 PUFA with total mortality varied by age, sex, race, or plasma n-3 PUFA. Evaluating both n-6 and n-3 PUFA, lowest risk was evident with highest levels of both.ConclusionsHigh circulating linoleic acid, but not other n-6 PUFA, was inversely associated with total and CHD mortality in older adults.

Dataset Information

Omega-3 polyunsaturated fatty acids modify the inverse association between systemic inflammation and cardiovascular fitness.

Background and objective

Approach and results

Conclusions

Publications

Omega-3 polyunsaturated fatty acids modify the inverse association between systemic inflammation and cardiovascular fitness.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets