CGRP induces migraine-like symptoms in mice during both the active and inactive phases.

ABSTRACT:

Background

Circadian patterns of migraine attacks have been reported by patients but remain understudied. In animal models, circadian phases are generally not taken into consideration. In particular, rodents are nocturnal animals, yet they are most often tested during their inactive phase during the day. This study aims to test the validity of CGRP-induced behavioral changes in mice by comparing responses during the active and inactive phases.

Methods

Male and female mice of the outbred CD1 strain were administered vehicle (PBS) or CGRP (0.1 mg/kg, i.p.) to induce migraine-like symptoms. Animals were tested for activity (homecage movement and voluntary wheel running), light aversive behavior, and spontaneous pain at different times of the day and night.

Results

Periph

SUBMITTER: Wattiez AS 

PROVIDER: S-EPMC8243868 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature