Effect of vitamin E administered to men in infertile couples on sperm and assisted reproduction outcomes: a double-blind randomized study.

ABSTRACT:

Objective

To evaluate the influence on sperm parameters and in vitro fertilization (IVF) outcomes of the administration of 400 mg/day of vitamin E for 3 months to men from infertile couples who are undergoing IVF.

Design

Double-blind, placebo-controlled, randomized study.

Setting

Human reproduction unit of a university hospital.

Patients

A total of 101 couples, 50 in the vitamin E group and 51 in the placebo group, undergoing IVF, among whom 64.4% of cases had an abnormal spermiogram according to World Health Organization (WHO) criteria.

Interventions

Vitamin E (α-tocopherol), 400 mg daily by mouth for 3 months, with sperm analysis performed immediately before starting the treatment and 3 months later on the day of IVF.

Main outcome measures

WHO s

SUBMITTER: Matorras R 

PROVIDER: S-EPMC8244364 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature