High-Fat Diet Enhances Neutrophil Adhesion in LDLR-Null Mice Via Hypercitrullination of Histone H3.
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ABSTRACT:
SUBMITTER: Osaka M
PROVIDER: S-EPMC8246031 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Publications
High-Fat Diet Enhances Neutrophil Adhesion in LDLR-Null Mice Via Hypercitrullination of Histone H3.
Osaka Mizuko M Deushi Michiyo M Aoyama Jiro J Funakoshi Tomoko T Ishigami Akihito A Yoshida Masayuki M
JACC. Basic to translational science 20210519 6
Neutrophil adhesion on the atheroprone femoral artery of high-fat diet-fed low-density lipoprotein receptor-null mice was enhanced more than in wild-type mice. The inhibition of histone H3 citrullination of neutrophils reversed the enhancement of neutrophil adhesion, suggesting that hypercitrullination contributes to enhanced neutrophil adhesion. Furthermore, pemafibrate reduced the citrullination of histone H3 in these mice. Therefore, the hypercitrullination of histone H3 in neutrophils contri ...[more]
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