PRMT1 promotes the tumor suppressor function of p14^ARF and is indicative for pancreatic cancer prognosis.

ABSTRACT: The p14^ARF protein is a well-known regulator of p53-dependent and p53-independent tumor-suppressive activities. In unstressed cells, p14^ARF is predominantly sequestered in the nucleoli, bound to its nucleolar interaction partner NPM. Upon genotoxic stress, p14^ARF undergoes an immediate redistribution to the nucleo- and cytoplasm, where it promotes activation of cell cycle arrest and apoptosis. Here, we identify p14^ARF as a novel interaction partner and substrate of PRMT1 (protein arginine methyltransferase 1). PRMT1 methylates several arginine residues in the C-terminal nuclear/nucleolar localization sequence (NLS/NoLS) of p14^ARF . In the absence of cellular stress, these arginines are crucial for nucleolar localization of p14^ARF<

SUBMITTER: Repenning A 

PROVIDER: S-EPMC8246066 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature