Screening and identification of potential protein biomarkers for the early diagnosis of acute myocardial infarction.

ABSTRACT:

Background

Acute myocardial infarction (AMI) is the most serious type of heart disease. Clinically, there is an urgent need to discover diagnostic biomarkers for the early diagnosis of AMI.

Methods

Serum proteomic profiles in AMI patients, healthy controls, and stable angina pectoris (SAP) patients were explored and compared by iTRAQ-2DLC-MS/MS. The clinical data of AMI patients were also analyzed. Differentially expressed proteins were validated by enzyme linked immunosorbent assay (ELISA), and diagnostic models were constructed.

Results

A total of 39 differentially expressed proteins were identified in AMI patients. The results showed that the serum levels of apolipoprotein E (APOE) in AMI patients were notably higher than those in the healthy controls (P=0.0172). T

SUBMITTER: Shi LY 

PROVIDER: S-EPMC8246203 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature