Low serum IgG4 level: a potential diagnostic biomarker for IgA nephropathy.

ABSTRACT:

Background

In contrast to intense investigations of galactose-deficient immunoglobulin A (IgA)1 specific immunoglobulin G (IgG), little is known about the IgG subclasses in IgA nephropathy (IgAN). Low IgG4 levels in IgAN were noticed in our preliminary experiment. We aimed to verify the low IgG4 levels and investigate the related immune mechanism in IgAN.

Methods

A total of 112 healthy controls (HC) and 112 newly diagnosed IgAN patients were enrolled in this study. Patients with idiopathic membranous nephropathy (IMN), minimal change disease (MCD), or lupus nephritis (LN) were selected as disease controls (DC) (n=122). Serum IgG4 and IgG levels were detected by enzyme-linked immunosorbent assay (ELISA). The IgG4⁺ B, T helper 1 (Th1), and Th2 cells were measured by

SUBMITTER: Tian X 

PROVIDER: S-EPMC8246212 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature