The Application of the Tissue Microarray (TMA) Technology to Analyze Cerebral Organoids.

ABSTRACT: "Multi-Omics" technologies have contributed greatly to the understanding of various diseases by enabling researchers to accurately and rapidly investigate the molecular circuitry that connects cellular systems. The tissue-engineered, three-dimensional (3D), in vitro disease model "organoid" integrates the "omics" results in a model system, elucidating the complex links between genotype and phenotype. These 3D structures have been used to model cancer, infectious disease, toxicity, and neurological disorders. Here, we describe the advantage of using the tissue microarray (TMA) technology to analyze human-induced pluripotent stem cell-derived cerebral organoids. Compared with the conventional processing of individual samples, sectioning and staining of TMA slides are faster and can be automa

SUBMITTER: Biunno I 

PROVIDER: S-EPMC8246530 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature