An exercise intervention alters stool microbiota and metabolites among older, sedentary adults.

ABSTRACT:

Background

Physiologic aging has been associated with gut dysbiosis. Although short exercise interventions have been linked to beneficial changes in gut microbiota in younger adults, limited data are available from older populations. We hypothesized that exercise would produce beneficial shifts in microbiota and short-chain fatty acid (SCFA) levels in older persons.

Methods

Stool samples were collected before and at completion of a supervised 24-week cardiovascular and resistance exercise intervention among 50-75-year-old participants. SCFA levels were analyzed by gas chromatography and microbiome by 16S rRNA gene sequencing. Negative binomial regression models compared pre- and post-differences using false discovery rates for multiple comparison.

Results

A total of 2

SUBMITTER: Erlandson KM 

PROVIDER: S-EPMC8246564 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature