Ontology highlight
ABSTRACT:
SUBMITTER: Zhao X
PROVIDER: S-EPMC8247389 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Zhao Xing X Chen Qiuyang Q Cai Yujie Y Chen Danze D Bei Mingrong M Dong Hongyan H Xu Jianzhen J
Journal of Cancer 20210611 16
The RNA binding protein TRA2A, a member of the transformer 2 homolog family, plays a crucial role in the alternative splicing of pre-mRNA. However, it remains unclear whether TRA2A is involved in non-coding RNA regulation and, if so, what are the functional consequences. By analyzing expression profiling data, we found that TRA2A is highly expressed in esophageal cancer and is associated with disease-free survival and overall survival time. Subsequent gain- and loss-of-function studies demonstra ...[more]