Ontology highlight
ABSTRACT:
SUBMITTER: Lisztes E
PROVIDER: S-EPMC8247843 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Lisztes Erika E Mező Erika E Demeter Fruzsina F Horváth Lilla L Bősze Szilvia S István Tóth Balázs B Borbás Anikó A Herczeg Mihály M
ChemMedChem 20210212 9
The design and synthesis of heparin mimetics with high anticancer activity but no anticoagulant activity is an important task in medicinal chemistry. Herein, we present the efficient synthesis of five Glc-GlcA-Glc-sequenced and one Glc-IdoA-Glc-sequenced non-glycosaminoglycan, heparin-related trisaccharides with various sulfation/sulfonylation and methylation patterns. The cell growth inhibitory effects of the compounds were tested against four cancerous human cell lines and two non-cancerous ce ...[more]