The incidence of thrombocytopenia in adult patients receiving chemotherapy for solid tumors or hematologic malignancies.

ABSTRACT:

Objectives

To estimate the risk of thrombocytopenia in various cancers and chemotherapy regimens.

Methods

Structured patient-level data from the Flatiron Health Electronic Health Record database were used to identify adult patients who received chemotherapy for a solid tumor or hematologic malignancy from 2012 to 2017. Three-month cumulative incidence of thrombocytopenia was assessed based on platelet counts, overall and by grade of thrombocytopenia. Co-occurrence of anemia, neutropenia, and leukopenia was evaluated.

Results

Of 15,521 patients with solid tumors, 13% had thrombocytopenia within 3 months (platelet count < 100 × 10⁹ /L); 4% had grade 3 (25 to < 50 × 10⁹ /L), and 2% grade 4 (<25 × 10⁹ /L) thrombocytopenia. Of 2537 patients

SUBMITTER: Shaw JL 

PROVIDER: S-EPMC8248430 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature