Gene signature of children with severe respiratory syncytial virus infection.

ABSTRACT:

Background

The limited treatment options for children with severe respiratory syncytial virus (RSV) infection highlights the need for a comprehensive understanding of the host cellular response during infection. We aimed to identify host genes that are associated with severe RSV disease and to identify drugs that can be repurposed for the treatment of severe RSV infection.

Methods

We examined clinical data and blood samples from 37 hospitalized children (29 mild and 8 severe) with RSV infection. We tested RNA from blood samples using next-generation sequencing to profile global mRNA expression and identify cellular processes.

Results

Retractions, decreased breath sounds, and tachypnea were associated with disease severity. We observed upregulation of genes related to

SUBMITTER: Dapat C 

PROVIDER: S-EPMC8249238 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature