Intranasal Fentanyl for Intervention-Associated Breakthrough Pain After Cardiac Surgery.

ABSTRACT:

Background

Cardiac bypass surgery patients have early postoperative interventions that elicit breakthrough pain. We evaluated the use of intranasal fentanyl for breakthrough pain management in these patients.

Methods

Multimodal analgesia (paracetamol 1 g three times a day, oxycodone 2-3 mg boluses with a patient-controlled intravenous pump) was used in 16 patients (age 49-70 years, weight 59-129 kg) after cardiac bypass surgery. Intranasal fentanyl 100 µg or 200 µg was used to manage breakthrough pain on the first and third postoperative mornings in a randomised order. Blood samples were collected for up to 3 h after fentanyl administration, pain was assessed with a numeric rating scale of 0-10. Plasma fentanyl concentration was assayed using liquid chromatography-mass spect

SUBMITTER: Valtola A 

PROVIDER: S-EPMC8249268 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature