HLA-B and cysteinylated ligands distinguish the antigen presentation landscape of extracellular vesicles.

ABSTRACT: Extracellular vesicles can modulate diverse processes ranging from proliferation and tissue repair, to chemo-resistance and cellular differentiation. With the advent of tissue and immunological targeting, extracellular vesicles are also increasingly viewed as promising vectors to deliver peptide-based cancer antigens to the human immune system. Despite the clinical relevance and therapeutic potential of such 'cell-free' approaches, the natural antigen presentation landscape exported in extracellular vesicles is still largely uncharted, due to the challenging nature of such preparations and analyses. In the context of therapeutic vesicle production, a critical evaluation of the similarity in vesicular antigen presentation is also urgently needed. In this work, we compared the HLA-I peptide

SUBMITTER: Bauza-Martinez J 

PROVIDER: S-EPMC8249458 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature