Ontology highlight
ABSTRACT:
SUBMITTER: Katoh TA
PROVIDER: S-EPMC8249593 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Katoh Takanobu A TA Daiho Takashi T Yamasaki Kazuo K Danko Stefania S Fujimura Shoko S Suzuki Hiroshi H
Scientific reports 20210701 1
The sarcoendoplasmic reticulum Ca<sup>2+</sup>-ATPase (SERCA) transports Ca<sup>2+</sup> ions across the membrane coupled with ATP hydrolysis. Crystal structures of ligand-stabilized molecules indicate that the movement of actuator (A) domain plays a crucial role in Ca<sup>2+</sup> translocation. However, the actual structural movements during the transitions between intermediates remain uncertain, in particular, the structure of E2PCa<sub>2</sub> has not been solved. Here, the angle of the A-do ...[more]