Ontology highlight
ABSTRACT:
SUBMITTER: Park S
PROVIDER: S-EPMC8249880 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Park Seulki S Kim Kidae K Haam Keeok K Ban Hyun Seung HS Kim Jung-Ae JA Park Byoung Chul BC Park Sung Goo SG Kim Sunhong S Kim Jeong-Hoon JH
BMB reports 20210601 6
Cereblon (CRBN) is a multi-functional protein that acts as a substrate receptor of the E3 ligase complex and a molecular chaperone. While CRBN is proposed to function in mitochondria, its specific roles are yet to be established. Here, we showed that knockdown of CRBN triggers oxidative stress and calcium overload in mitochondria, leading to disruption of mitochondrial membrane potential. Notably, long-term CRBN depletion using PROteolysis TArgeting Chimera (PROTAC) induced irreversible mitochon ...[more]