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CAR-T Cell Therapy: Mechanism, Management, and Mitigation of Inflammatory Toxicities.

ABSTRACT: Engineered T cell therapies such as chimeric antigen receptor (CAR) expressing T cells (CAR-T cells) have great potential to treat many human diseases; however, inflammatory toxicities associated with these therapies present safety risks and can greatly limit its widespread use. This article briefly reviews our current understanding of mechanisms for inflammatory toxicities during CAR T-cell therapy, current strategies for management and mitigation of these risks and highlights key areas of knowledge gap for future research.

SUBMITTER: Fischer JW

PROVIDER: S-EPMC8250150 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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CAR-T Cell Therapy: Mechanism, Management, and Mitigation of Inflammatory Toxicities.

Fischer Joseph W JW Bhattarai Nirjal N

Frontiers in immunology 20210618

Engineered T cell therapies such as chimeric antigen receptor (CAR) expressing T cells (CAR-T cells) have great potential to treat many human diseases; however, inflammatory toxicities associated with these therapies present safety risks and can greatly limit its widespread use. This article briefly reviews our current understanding of mechanisms for inflammatory toxicities during CAR T-cell therapy, current strategies for management and mitigation of these risks and highlights key areas of know ...[more]

PMID: 34220853

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