Ontology highlight
ABSTRACT:
SUBMITTER: Anzurez A
PROVIDER: S-EPMC8251239 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Anzurez Alitzel A Naka Izumi I Miki Shoji S Nakayama-Hosoya Kaori K Isshiki Mariko M Watanabe Yusuke Y Nakamura-Hoshi Midori M Seki Sayuri S Matsumura Takayuki T Takano Tomohiro T Onodera Taishi T Adachi Yu Y Moriyama Saya S Terahara Kazutaka K Tachikawa Natsuo N Yoshimura Yoshihiro Y Sasaki Hiroaki H Horiuchi Hiroshi H Miyata Nobuyuki N Miyazaki Kazuhito K Koga Michiko M Ikeuchi Kazuhiko K Nagai Hiroyuki H Saito Makoto M Adachi Eisuke E Yotsuyanagi Hiroshi H Kutsuna Satoshi S Kawashima Akira A Miyazato Yusuke Y Kinoshita Noriko N Kouno Chiyoko C Tanaka Kensuke K Takahashi Yoshimasa Y Suzuki Tadaki T Matano Tetsuro T Ohashi Jun J Kawana-Tachikawa Ai A
HLA 20210413 1
HLA-A, -C, -B, and -DRB1 genotypes were analyzed in 178 Japanese COVID-19 patients to investigate the association of HLA with severe COVID-19. Analysis of 32 common HLA alleles at four loci revealed a significant association between HLA-DRB1*09:01 and severe COVID-19 (odds ratio [OR], 3.62; 95% CI, 1.57-8.35; p = 0.00251 [permutation p value = 0.0418]) when age, sex, and other common HLA alleles at the DRB1 locus were adjusted. The DRB1*09:01 allele was more significantly associated with risk fo ...[more]