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Association of HLA-DRB1*09:01 with severe COVID-19.


ABSTRACT: HLA-A, -C, -B, and -DRB1 genotypes were analyzed in 178 Japanese COVID-19 patients to investigate the association of HLA with severe COVID-19. Analysis of 32 common HLA alleles at four loci revealed a significant association between HLA-DRB1*09:01 and severe COVID-19 (odds ratio [OR], 3.62; 95% CI, 1.57-8.35; p = 0.00251 [permutation p value = 0.0418]) when age, sex, and other common HLA alleles at the DRB1 locus were adjusted. The DRB1*09:01 allele was more significantly associated with risk for severe COVID-19 compared to preexisting medical conditions such as hypertension, diabetes, and cardiovascular diseases. These results indicate a potential role for HLA in predisposition to severe COVID-19.

SUBMITTER: Anzurez A 

PROVIDER: S-EPMC8251239 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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Association of HLA-DRB1*09:01 with severe COVID-19.

Anzurez Alitzel A   Naka Izumi I   Miki Shoji S   Nakayama-Hosoya Kaori K   Isshiki Mariko M   Watanabe Yusuke Y   Nakamura-Hoshi Midori M   Seki Sayuri S   Matsumura Takayuki T   Takano Tomohiro T   Onodera Taishi T   Adachi Yu Y   Moriyama Saya S   Terahara Kazutaka K   Tachikawa Natsuo N   Yoshimura Yoshihiro Y   Sasaki Hiroaki H   Horiuchi Hiroshi H   Miyata Nobuyuki N   Miyazaki Kazuhito K   Koga Michiko M   Ikeuchi Kazuhiko K   Nagai Hiroyuki H   Saito Makoto M   Adachi Eisuke E   Yotsuyanagi Hiroshi H   Kutsuna Satoshi S   Kawashima Akira A   Miyazato Yusuke Y   Kinoshita Noriko N   Kouno Chiyoko C   Tanaka Kensuke K   Takahashi Yoshimasa Y   Suzuki Tadaki T   Matano Tetsuro T   Ohashi Jun J   Kawana-Tachikawa Ai A  

HLA 20210413 1


HLA-A, -C, -B, and -DRB1 genotypes were analyzed in 178 Japanese COVID-19 patients to investigate the association of HLA with severe COVID-19. Analysis of 32 common HLA alleles at four loci revealed a significant association between HLA-DRB1*09:01 and severe COVID-19 (odds ratio [OR], 3.62; 95% CI, 1.57-8.35; p = 0.00251 [permutation p value = 0.0418]) when age, sex, and other common HLA alleles at the DRB1 locus were adjusted. The DRB1*09:01 allele was more significantly associated with risk fo  ...[more]

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