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Enantio- and Diastereoselective, Complete Hydrogenation of Benzofurans by Cascade Catalysis.

ABSTRACT: We report an enantio- and diastereoselective, complete hydrogenation of multiply substituted benzofurans in a one-pot cascade catalysis. The developed protocol facilitates the controlled installation of up to six new defined stereocenters and produces architecturally complex octahydrobenzofurans, prevalent in many bioactive molecules. A unique match of a chiral homogeneous ruthenium-N-heterocyclic carbene complex and an in situ activated rhodium catalyst from a complex precursor act in sequence to enable the presented process.

SUBMITTER: Moock D

PROVIDER: S-EPMC8251578 | biostudies-literature |

REPOSITORIES: biostudies-literature

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