Surprising Homolytic Gas Phase Co-C Bond Dissociation Energies of Organometallic Aryl-Cobinamides Reveal Notable Non-Bonded Intramolecular Interactions.

ABSTRACT: Aryl-cobalamins are a new class of organometallic structural mimics of vitamin B₁₂ designed as potential 'antivitamins B₁₂ '. Here, the first cationic aryl-cobinamides are described, which were synthesized using the newly developed diaryl-iodonium method. The aryl-cobinamides were obtained as pairs of organometallic coordination isomers, the stereo-structure of which was unambiguously assigned based on homo- and heteronuclear NMR spectra. The availability of isomers with axial attachment of the aryl group, either at the 'beta' or at the 'alpha' face of the cobalt-center allowed for an unprecedented comparison of the organometallic reactivity of such pairs. The homolytic gas-phase bond dissociation energies (BDEs) of the coordination-isomeric phenyl- and 4-ethylphenyl-cobinamides were determined by ESI-MS threshold CID experiments, furnishing (Co-C sp2 )-BDEs of 38.4 and 40.6 kcal mol^-1 , respectively, for the two β-isomers, and the larger BDEs of 46.6 and 43.8 kcal mol^-1 for the corresponding α-isomers. Surprisingly, the observed (Co-C sp2 )-BDEs of the Co_β -aryl-cobinamides were smaller than the (Co-C sp3 )-BDE of Co_β -methyl-cobinamide. DFT studies and the magnitudes of the experimental (Co-C sp2 )-BDEs revealed relevant contributions of non-bonded interactions in aryl-cobinamides, notably steric strain between the aryl and the cobalt-corrin moieties and non-bonded interactions with and among the peripheral sidechains.

SUBMITTER: Tsybizova A 

PROVIDER: S-EPMC8251903 | biostudies-literature |

REPOSITORIES: biostudies-literature