Multicomponent Self-Assembly of a Giant Heterometallic Polyoxotungstate Supercluster with Antitumor Activity.

ABSTRACT: The hierarchical aggregation of molecular nanostructures from multiple components is a grand synthetic challenge, which requires highly selective linkage control. We demonstrate how two orthogonal linkage groups, that is, organotin and lanthanide cations, can be used to drive the aggregation of a giant molecular metal oxide superstructure. The title compound {[(Sn(CH₃ )₂ )₂ O]₄ {[CeW₅ O₁₈ ] [TeW₄ O₁₆ ][CeSn(CH₃ )₂ ]₄ [TeW₈ O₃₁ ]₄ }₂ }^46- (1 a) features dimensions of ca. 2.2×2.3×3.4 nm³ and a molecular weight of ca. 25 kDa. Structural analysis shows the hierarchical aggregation from several independent subunits. Initial biomedical tests show that 1 features an inhibitory effect on the proliferation of HeLa cells based on an apoptosis pathway. In vivo experiments in mice reveal the antiproliferative activity of 1 and open new paths for further development of this new compound class.

SUBMITTER: Liu JC 

PROVIDER: S-EPMC8252014 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature