Ontology highlight
ABSTRACT:
SUBMITTER: Hyeraci M
PROVIDER: S-EPMC8252049 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Hyeraci Mariafrancesca M Scalcon Valeria V Folda Alessandra A Labella Luca L Marchetti Fabio F Samaritani Simona S Rigobello Maria Pia MP Dalla Via Lisa L
ChemMedChem 20210406 12
Resistance to platinum-based anticancer drugs represents an important limit for their clinical effectiveness and one of the most important field of investigation in the context of platinum compounds. From our previous studies, Pt<sup>II</sup> complexes containing the triphenylphosphino moiety have been emerging as promising agents, showing significant cytotoxicity to resistant ovarian carcinoma cells. Two brominated triphenylphosphino trans-platinum derivatives were prepared and evaluated on hum ...[more]