The infant gut resistome is associated with E. coli and early-life exposures.

ABSTRACT:

Background

The human gut microbiome harbors a collection of bacterial antimicrobial resistance genes (ARGs) known as the resistome. The factors associated with establishment of the resistome in early life are not well understood. We investigated the early-life exposures and taxonomic signatures associated with resistome development over the first year of life in a large, prospective cohort in the United States. Shotgun metagenomic sequencing was used to profile both microbial composition and ARGs in stool samples collected at 6 weeks and 1 year of age from infants enrolled in the New Hampshire Birth Cohort Study. Negative binomial regression and statistical modeling were used to examine infant factors such as sex, delivery mode, feeding method, gestational age, antibiotic exposure,

SUBMITTER: Lebeaux RM 

PROVIDER: S-EPMC8252198 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature