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Disentangling Mechanisms Behind Chronic Lethality through Toxicokinetic-Toxicodynamic Modeling.


ABSTRACT: Ecotoxicological profiles of the 3 insecticides imidacloprid, thiacloprid, and flupyradifurone in terms of acute and chronic effects were analyzed in Chironomus riparius. Toxicokinetic-toxicodynamic modeling revealed that chironomids would die from starvation as a result of prolonged feeding inhibition under chronic exposures. The starvation effect is an indirect cause for mortality, which, for the neonicotinoids, adds to the direct/acute mortality, although the results suggests that this additional effect is not relevant for flupyradifurone. Environ Toxicol Chem 2021;40:1706-1712. © 2021 Bayer Inc. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.

SUBMITTER: Gergs A 

PROVIDER: S-EPMC8252366 | biostudies-literature |

REPOSITORIES: biostudies-literature

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