Ontology highlight
ABSTRACT:
SUBMITTER: Tauber C
PROVIDER: S-EPMC8252737 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20210506 24
The generation of bioactive molecules from inactive precursors is a crucial step in the chemical evolution of life, however, mechanistic insights into this aspect of abiogenesis are scarce. Here, we investigate the protein-catalyzed formation of antivirals by the 3C-protease of enterovirus D68. The enzyme induces aldol condensations yielding inhibitors with antiviral activity in cells. Kinetic and thermodynamic analyses reveal that the bioactivity emerges from a dynamic reaction system including ...[more]