Treating sepsis with vitamin C, thiamine, and hydrocortisone: Exploring the quest for the magic elixir.

ABSTRACT: The administration of ascorbic acid (vitamin C) alone or in combination with thiamine (vitamin B1) and corticosteroids (VCTS) has recently been hypothesized to improve hemodynamics, end-organ function, and may even increase survival in critically ill patients. There are several clinical studies that have investigated the use of vitamin C alone or VCTS in patients with sepsis and septic shock or are ongoing. Some of these studies have demonstrated its safety and potential benefit in septic patients. However, many questions remain regarding the optimal dosing regimens and plasma concentrations, timing of administration, and adverse effects of vitamin C and thiamine. These questions exist because the bulk of research regarding the efficacy of vitamin C alone or in combination with thiamine an

SUBMITTER: Obi J 

PROVIDER: S-EPMC8254386 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature